SYNTHESIS, STRUCTURE AND BIOLOGICAL ACTIVITY OF HYDROXAMIC ACID COMPOUNDS ATTACHED TO HETEROCYCLIC FUROXAN FROM EUGENOL, THE MAIN COMPONENT OF OCUMUM SANCTUM L. OIL

Abstract

Esterize 4,5-dimethoxy-2-(3-methylfuroxan-4-yl)phenylamine reacted with hydroxylamine to obtain 3 hydroxamic acid  compounds. These compounds have been measuredby IR, ¹H NMR, ¹³C NMR, MS to determine their structures. The anticancer activities of 3 compounds were tested, the results showed that the 2 compounds were resistant to 2-3 cancer lines HepG2, A549 and KB. The results of testing the anti-cancer activity of 3 hydroxamic acid showed that compounds 7, 9 have the ability to fight against 2-3 cancer lines.