TỔNG HỢP VÀ NGHIÊN CỨU CẤU TRÚC MỘT SỐ DẪN XUẤT BENZENESULFONAMIDE CÓ CHỨA DỊ VÒNG BENZOTHIAZOLE
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Abstract
Three benzothiazole aniline derivatives, namely 2a, 2b, and 2c, were successfully synthesized through the reduction reaction of nitro compounds using Na2S2O4 as the reducing agent in C2H5OH solvent, yielding approximately 75%. Upon reacting three benzothiazole anilines, 2a, 2b, and 2c, with TsCl, three benzenesulfonamide derivatives, 3a, 3b, and 3c, were obtained with an efficiency ranging from 72% to 80%. The structures of 3a, 3b, and 3c were accurately determined using modern spectroscopic methods including IR, NMR, and MS. Furthermore, compounds 3a, 3b, and 3c exhibited antimicrobial activity against certain bacterial and fungal strains, with MIC values ranging from 150 to 200 µg/ml.
Keywords: Benzothiazole aniline, benzenesulfonamide, microwave, antimicrobial activity.