NGHIÊN CỨU TỔNG HỢP VÀ PHỔ CỘNG HƯỞNG TỪ HẠT NHÂN CỦA MỘT SỐ HỢP CHẨT AMIDE VÀ IMIDE CÓ CHỨA DỊ VÒNG FUROXAN TỪ EUGENOL

Abstract

From eugenol in Ocimum sanctum L. oil, 3-methyl-4-(2-amino-4,5-dimethoxyphenyl) furoxan (1) was synthesized. The reaction of 1 with maleic anhydride was amide 2. The double bond in 2 has trans configuration which is different from the original cis configuration o f maleic anhydride. For succinic anhydride, the results showed that when the reaction was conducted at different temperactures, the product was amide 3, a mixture of two imide isomers of position N ^ o , and imide 4 was not isomerized to the position N ^ o group. The NMR signals o f three amide and imide were assigned using their spin-spin splitting patterns, and HMBC cross peaks. The antimicrobial activity 1 compound was tested.
Keywords: Amide, imide, NMR spectra.