SYNTHESIS, STRUCTURAL CHARACTERIZATION, BIOLOGICAL ACTIVITY OF COMPLEXES OF Mn(II), Cu(II) WITH 6-HYDROXY-3-SULFOQUINOL-7-YLOXYACETIC ACID
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Tóm tắt
A novel quinoline derivative, 6-hydroxy-3-sulfoquinoline-7-yloxyacetic acid (Q), was successfully synthesized from eugenol, a major component of basil essential oil. Its corresponding complexes [Mn(C₁₁H₇O₇NS)(H₂O)₂]·H₂O (B1), [Cu(C11H6O7NS)(H2O)2].H2O (B2) were obtained through direct coordination between Mn²⁺, Cu²⁺ and ligand Q. The proposed structure of B1, B2 were elucidated based on a comprehensive analysis of EDX, ESI-MS, IR spectroscopy, and thermal gravimetric data. In these complexes, the ligand Q coordinated to the Mn(II) center via the oxygen of OH phenol group, H2O and O of COO group, resulting in a stable four-coordinate environment. The results of the antimicrobial activity test of the B1and B2omplexes showed that both complexes had high activity against Bacillus subtilis and Lactobacillus fermentum strains, corresponding to low IC50 values ranging from 2.58 to 10.81 μg/mL.
Từ khóa
Mn(II), Cu(II) complexes, sulfoquinoline, structural, biological activity.
Chi tiết bài viết
Tài liệu tham khảo
(dimethylamino)styryl]-1-methylquinolineium iodide: A case of negative solvatochromism in water, The Journal of Physical Chemistry B, 115(37), 10983-10989.
[2] Flavia A. (2007), Near-Infrared Luminescent Lanthanide Complexes of Quinolineol Ligands: Structure/Properties Relationship, PhD thesis, University of Cagliari, Italia.
[3] Narayanachara, Shreedhar D. D., Venkatesh K. M., Vasanth R. (2012), Synthesis, spectral characterization, antimicrobial and cytotoxicity studies of some lanthanide(III) complexes of quinoline derivatives, Journal of Chemical and Pharmaceutical Research, 4(7), 3446-3453.
[4] Wei C., Wei H., Yan W., Zhao Z., Cai Z., Sul B., Huang C. (2016), WaterSoluble and Highly Luminescent Europium(III) Complexes with Favorable Photostability and Sensitive pH Response Behavior, Inorganic Chemistry, 55(20), 10645–10653.
[5] Nguyen Huu Dinh, Le Van Co, Nguyen Minh Tuan, Le Thi Hong Hai Hai, Luc Van Meervelt (2012), New route to novel polysubstituted quinolines starting with eugenol, the main constituent of Ocimum sanctum L. oil, Heterocycles, 85(3), 627-637.