Alpha glucosidase inhibitory activity of extracts and compounds from Zingiber zerumbet Linn rhizomes
Nội dung chính của bài viết
Tóm tắt
The total methanol residue, n-hexane and chloroform extracts from Zingiber zerumbet Linn rhizomes have been evaluated for α-glucosidase inhibitory activity in an attempt to identify potential active ingredients in natural products. The results showed that the chloroform extract inhibited α-glucosidase more effectively than the positive control acarbose, with an IC50 value of 126.9 µg/mL. Chemical investigation of the chloroform extract led to the isolation of naringenin (1). The compound 1 expressed strong α-glucosidase inhibitory activity with respective IC50 values of 19.6 µM, which are two-fold and eleven-fold lower than that of acarbose (IC50 214.1 µM). The research demonstrated the α-glucosidase inhibitory activity of the Zingiber zerumbet Linn rhizome as potential antidiabetic agents.
Từ khóa
Zingiber zerumbet, chloroform extract, α-glucosidase, aromadendrin, naringenin
Chi tiết bài viết
Tài liệu tham khảo
2. Kirtikar RK, Basu BD. Indian medicinal plant. Allahabad: Lalit Mohan Basu Publications 1984, pp. 2415-2419.
3. Saadiah M. S., Halijah I. Proceedings of the National Convention on Herbal medicine. Kuala Lumpur: Forest Research Institute Malaysia 1995, pp. 205-207.
4. Bhuiyan M. N. I., Chowdhury J. U., Begum J. Chemical investigation of the leaf and rhizome essential oils of Zingiber zerumbet (L.) Smith from Bangladesh. Bangladesh J Pharmacol 2009, 4(1), pp. 9-12.
5. Zakaria Z. A., Mohamad A. S., Chear C. T., Wong Y. Y., Israf D. A., Sulaiman M. R. Antiinflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems. Med Princ Pract 2010, 19(4), pp. 287-294.
6. Zakaria Z. A., Mohamad A. S., Ahmad M. S., Mokhtar A. F., Israf D. A., Lajis N. H., et al. Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet. Biol Res Nurs 2011, 13(4), pp. 425-432.
7. Sulaiman M. R., Tengku Mohamad T. A. S., Shaik Mossadeq W. M., Moin S., Yusof M., Mokhtar A. F., et al. Antinociceptive activity of the essential oil of Zingiber zerumbet. Planta Med 2010, 76(2), pp. 107-112.
8. Do Tat Loi. Vietnamese medicinal plants and herbs. Medical Publisher, Hanoi, Vietnam, 2004.
9. Kim M., Miyamoto S., Yasui Y., Oyama T., Murakami A., Tanaka T. Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice. Int J Cancer 2009, 124, pp. 264-271.
10. Sung B., Jhurani S., Ahn K. S., Mastuo Y., Yi T., Guha S., et al. Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. Cancer Res 2008, 68, pp. 8938-8944.
11. Sakinah S. A. S., Handayani S. T., Hawariah L. P. A. Zerumbone induced apoptosis in liver cancer, HepG2 cells via modulation of Bax/ Bcl-2 ratio. Cancer Cell Int 2007, 7, pp. 4.
12. Vimala S., Norhanom A. W., Yadav M. Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine. Br J Cancer 1999, 80, pp. 110-116.
13. I. C. Nigam, L. Levi. Column and gas chromatographic analysis of oil of wild ginger. Identification and estimation of some new constituents. Can. J. Chem 1963, 41, pp. 1726–1730
14. N. P. Damodaran, S. Dev. Studies in sesquiterpenes – XXXVIII, Structure of humulene epoxide-I and humulene epoxide-II. Tetrahedron 1968, 24, pp. 4123–4132.
15. N. P. Damodaran, S. Dev. Studies in sesquiterpenes – XXXVIII, Sesquiterpenoids from the essential oil of Zingiber zerumbet Smith. Tetrahedron 1968, 24, pp. 4113–4122.
16. N. P. Damodaran, S. Dev. Studies in sesquiterpenes – XXXVIII, Structure of humulenols. Tetrahedron 1968, 24, pp. 4133–4142.
17. C. M. Jimmy, V. Robert, C. J. Claude. Chemical composition of the essential oil from rhizomes, leaves and flowers of Zingiber zerumbet Smith from Reunion Island. Journal of Essential Oil Research 2003, 15(3), pp. 202-205.
18. T. Y. Chen, L. G. Chen, C. J. Lee, F. Y. Lee, C. C. Wang. Anti-inflammatory constituents of Zingiber zerumbet. Food Chem 2008, 110, pp. 584–589.
19. Sulaiman M. R., Perimal E. K., Zakaria Z. A., Mokhtar F., Akhtar M. N., Lajis N. H., et al. Preliminary analysis of the antinociceptive activity of zerumbone. Fitoterapia 2009, 80(4), pp. 230-232.
20. Murakami A, Takahashi M, Jiwajinda S, Koshimizu K, Ohigashi H. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetateinduced Epstein-Barr virus activation. Biosci Biotechnol Biochem 1999, 63, pp. 1811-1812.
21. Sulaiman MR, Perimal EK, Akhtar MN, Mohamad AS, Khalid MH, Tasrip NA, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia 2010, 81, pp. 855-858.
22. Chaung HC, Ho CT, Huang TC. Anti-hypersensitive and antiinflammatory activities of water extract of Zingiber zerumbet (L.) Smith. Food Agric Immunol 2008, 19(2), pp. 117-129.
23. Chien T. Y., Chen L. G., Lee C. J., Lee F. Y., Wang C. C. Anti-inflammatory constituents of Zingiber zerumbet. Food Chem 2008, 110(3), pp. 584-589.
24. Jantan I, Raweh SM, Sirat HM, Jamil S, Mohd Yasin YH, Jalil J, et al. Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. Phytomedicine 2008, 15(4), pp. 306-309.
25. Abdullah NH, Salim F, Ahmad R. Chemical Constituents of Malaysian U. cordata var. ferruginea and their in vitro α-glucosidase inhibitory activities. Molecules 2016, 21(5), pp. 525.
26. N. Al-Musayeib, S. Perveen, I. Fatima, M. Nasir, A. Hussain. “Antioxidant, anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis”. Molecules 2011, 16, pp. 10214 -10226.
27. L. A. L. da Silva, L. G. Faqueti, F. H. Reginatto, A. D. C. dos Santos, A. Barison, M. W. Biavatti. Phytochemical analysis of Vernonanthura tweedieana and a validated UPLC-PDA method for the quantification of eriodictyol. Brazilian journal of pharmacognosy 2015, 25, pp. 375-381.